ITP team, RevBio, Advances Dental Implant Stabilization Trials•ITP team, RevBio, Advances Dental Implant Stabilization Trials•Please join us @ the 2025 Translational Resource Center Networking Exchange: April 22-23, 2025 | Boston, MA•Congratulations to our Interdisciplinary Translational Project team at GreenMark Biomedical Inc on their recent publication in the Journal of the American Dental Association - Foundational Science!•ITP RevBio Receives FDA approval for a first in-human Clinical Trial!•ITP PI, Dr. Isabelle Lombaert wins the 2023 University of Michigan Medical School’s Frankel Innovation Initiative Award!•RevBio Awarded a $3.4 Million NIH Grant•MPWRM Resource Center and DOCTRC were highlighted in the keynote talk at NIDCR's 75th anniversary event, NIDCR at 75: Celebrating the Past, Charting the Future•RevBio Receives ISO 13485 Certification for its Quality Management System!•GreenMark Biomedical Launches CrystLCare™ Biorestorative, Fluoride-Free!

Manufacturing Services

Prototyping and Process for Manufacturing, Wyss Institute

Ability to produce:

  • Biopolymer based hydrogels/cryogels
  • Polymer-based porous scaffolds
  • Polymer-based nano/micro particles
  • Lipid-based nano/micro particles
  • Polymer-based aggregates

Analytical expertise:

  • Drug release profiling by HPLC, SEC, GPC, Ion Exchange chromatography, fluorescence, luminescence, absorbance, Native-PAGE, SDS-PAGE, Western Blots, Agarose Gels, ELISAs/Titers, LC/MS, numerous other product specific assays including cell based assays.
  • Material characterization: Dynamic light scattering, rheology, NMR, IR, SEM, TEM, numerous other product specific assays.

Translational Capabilities:

  • Process and analytical qualification and validation capabilities
  • Support good laboratory practice (GLP) toxicity & biocompatibility testing, regulatory submissions, and in some cases early stage human clinical trials.

Instrumentation:

  • LC/MS, fluorescent/absorbance plate-reader
  • HPLC (reverse phase, size exclusion, ion exchange, hydrophilic)
  • Dynamic Light Scattering DLS
  • Zeta potential (Zetasizer)
  • Rheometer

Contact translationalrc@umich.edu for specific guidance and/or additional information about the manufacturing services or facilities available.