"Congratulations to our ITP team, GreenMark Biomedical, on their NIH Funding for AI-Enabled Early Caries Detection!"•"Congratulations to our ITP team, GreenMark Biomedical, on their NIH Funding for AI-Enabled Early Caries Detection!"•ITP team, RevBio, Advances Dental Implant Stabilization Trials•ITP team, RevBio, Advances Dental Implant Stabilization Trials•Please join us @ the 2025 Translational Resource Center Networking Exchange: April 22-23, 2025 | Boston, MA•Congratulations to our Interdisciplinary Translational Project team at GreenMark Biomedical Inc on their recent publication in the Journal of the American Dental Association - Foundational Science!•ITP RevBio Receives FDA approval for a first in-human Clinical Trial!•ITP PI, Dr. Isabelle Lombaert wins the 2023 University of Michigan Medical School’s Frankel Innovation Initiative Award!•RevBio Awarded a $3.4 Million NIH Grant•MPWRM Resource Center and DOCTRC were highlighted in the keynote talk at NIDCR's 75th anniversary event, NIDCR at 75: Celebrating the Past, Charting the Future

ABOUT

Reconstruction of dental, oral, and craniofacial (DOC) tissues through tissue engineering and regenerative medicine (RM) is a major goal in dentistry. Despite the continuing success and commercial viability of RM approaches in selected areas of medicine, the application of RM concepts to DOC problems has not been well-implemented in clinical practice. To meet this need, the Michigan-Pittsburgh-Wyss Regenerative Medicine Resource Center (MPWRM RC), rebranded as the Translational Resource Center (TRC), in 2024 was established as an interdisciplinary partnership amongst the University of Michigan, the University of Pittsburgh, and the Wyss Institute, along with technology, clinical, regulatory, marketing, and commercial translation experts from private practice and industry. Through this collaborative effort, we will accelerate clinical adoption of promising technologies by providing the interdisciplinary expertise and resources to guide technologies towards FDA submissions.

MPWRM Resource Center Organizational Chart

With the ITP Project Teams as integral components of the MPWRM RC, our organizational structure will promote a collaborative and interdisciplinary approach to technology translation towards clinical adoption.


MPWRM Resource Center Leadership

  • Steering Committee (includes NIDCR directors + RC PIs) will direct overall effort for the RC and the ITPs
  • MPWRM Operating Committee (see Table 2) will provide leadership and advice to the MPWRM PIs regarding progress and direction of MPWRM RC

ITP Project Teams

  • ITP PIs and teams (laboratory personnel, staff), in conjunction with pre-existing Home Institution or Company Support (“external” to MPWRM), will work closely with MPWRM RC Cores to develop technology translation strategies and
    execute project plans

Customized ITP Support from MPWRM Resource Center

  • Teams (boxes with white border) comprised of RC subject matter experts, are categorized by activity: Advisory (in blue; provides expertise and advice to ITP Project Teams) or Core (in grey; provides deliverables/ performs work with
    ITP Project Team). The activities of most teams extend across both Advisory and Core roles. Activities of Commercial Translation/ Future Clinical Adoption team spans across activities of all Advisory and Core Teams
  • Scientific Cores at each of the 3 institutions provide technical services for ITPs. Some of the Advisory teams also support Scientific Core activities, as depicted by overlap into the Scientific Core (dark grey). Scientific Cores also
    collaborate with external Contract Research Services/ Support
  • Activities and communication throughout the RC will be supported by Project Management team

The Translational Resource Center is a partnership with NIH’s National Institute of Dental and Craniofacial Research

NIH/NIDCR

The mission of the National Institute of Dental and Craniofacial Research (NIDCR) is to improve dental, oral, and craniofacial health through research, research training, and the dissemination of health information. We accomplish our mission by:

  • Performing and supporting basic, translational, and clinical research;
  • Conducting and funding research training and career development programs to ensure an adequate number of talented, well-prepared, and diverse investigators;
  • Coordinating and assisting relevant research and research-related activities among all sectors of the research community;
  • Promoting the timely transfer of knowledge gained from research and its implications for health to the public, health professionals, researchers, and policy-makers.

To learn more about NIDCR please connect to: https://www.nidcr.nih.gov/

The Translational Resource Center is supported in part by the National Institute of Dental & Craniofacial Research of the National Institutes of Health under Award Number U24DE029462. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.