Rigorous application of biostatistics in reliable clinical research ensures that conclusions drawn are valid, reproducible, and useful for improving care in orthopaedics. Xiaoxiao Sun, PhD, Associate Professor, University of Arizona, and Joel Gagnier, MSc, PhD, Associate Professor, Western University Canada will present on applied biostatistics in orthopaedic studies. They will lead a discussion on propensity score analyses in clinical research and statistical and machine learning approaches for modeling longitudinal multimodal data.